This medicine is used for the treatment of nausea, vomiting, and symptoms of slow gastrointestinal motility (such as feeling of fullness, bloating, and post-prandial discomfort). Domperidone works by increasing stomach and intestinal movement, facilitating digestion and reducing nausea.
The consumption of this product is the responsibility of whoever recommends it and whoever uses it. Consult your doctor before consuming any medication.
THERAPEUTIC INDICATIONS: The dyspeptic symptom complex is often associated with delayed gastric emptying, gastroesophageal reflux esophagitis:
- Feeling at epigastric fullness, early satiety, feeling of abdominal distention, upper abdominal pain.
- Belching, flatulence.
- Nausea and vomiting.
- Heartburn with or without regurgitation of gastric contents into the mouth.
- Nausea and vomiting of functional origin, organic, infectious or dietetic or induced by radiation therapy or pharmacotherapy.
A specific indication is nausea and vomiting induced by dopamine agonists, such as those used in Parkinson's disease (such as L-dopa and bromocriptine).
CONTRAINDICATIONS: Motilium ® is contraindicated in the following situations:
Known hypersensitivity to domperidone or any of its excipients.
Prolactin-releasing pituitary tumor (prolactinoma).
Coadministration with oral ketoconazole, erythromycin, or other potent CYP3A4 inhibitors that prolong the QTc interval such as fluconazole, voriconazole, clarithromycin, amiodarone, and telithromycin.
Motilium ® should not be used in cases in which the stimulation of gastric motility might be dangerous, for example, gastrointestinal hemorrhage, mechanical obstruction or perforation.
CAUTIONS: When using antacids or antisecretory agents, concomitantly, they should be administered after meals and not before them, ie should not be administered simultaneously with the tablets and suspension Motilium ®.
Use Precautions: Enteric coated tablets contain lactose and may be unsuitable for patients with lactose intolerance, galactosemia, or malabsorption of glucose / galactose.
The oral suspension contains sorbitol and may be inadequate for patients intolerant to sorbitol.
Use in children: Because the metabolic and blood-brain barrier are not fully developed during the first months of life, Motilium ® as well as any medication that is administered to infants younger, should be used with caution and under close supervision care.
Since the typical absence of neurological side effects Motilium ® is due to the limited penetration through the blood brain barrier, the occurrence of these effects can not be totally excluded in babies under 1 year.
Use in hepatic impairment: Since domperidone is extensively metabolized in the liver, Motilium ® should be used with caution in patients with liver damage.
Use in renal impairment: In patients with severe renal insufficiency (serum creatinine> 6 mg/100 ml, for example,> 0.6 mmol / l) elimination half-life of domperidone is increased from 7.4 to 20.8 hours but plasma levels are lower than in healthy volunteers. Since a small amount of the drug is excreted by the kidneys, it is unlikely that the dose of a single acute dose needs to be adjusted in patients with renal failure. However, with repeated administration, frequency of administration should be reduced to once or twice daily depending on the severity of damage, and may also be necessary to reduce the dose.
Generally, patients with prolonged therapy should be reviewed regularly.
Effects on ability or use machines: Motilium ® does not affect mental alertness.
RESTRICTIONS OF USE DURING PREGNANCY AND LACTATION:
Use in pregnancy: There are limited post-marketing data on the use of domperidone in pregnant women. A study in rats has shown reproductive toxicity at high doses, is toxic to the mother. No one knows the potential risk to humans. Therefore, Motilium ® should be used during pregnancy only where justified by the anticipated therapeutic benefit.
DOSAGE AND ADMINISTRATION:
Adults and adolescents (over 12 years and weighing 35 kg or more):
Tablets: 1 to 2 tablets of 10 mg three to four times a day, with a maximum daily dose of 80 mg.
